Two Antibody-Guided Lactic-co-Glycolic Acid-Polyethylenimine (LGA-PEI) Nanoparticle Delivery Systems for Therapeutic Nucleic Acids

We beforehand reported a brand new polymer, lactic-co-glycolic acid-polyethylenimine (LGA-PEI), as an improved nanoparticle (NP) supply for therapeutic nucleic acids (TNAs). Right here, we additional developed two antibody (Ab)-conjugated LGA-PEI NP applied sciences for active-targeting supply of TNAs. LGA-PEI was covalently conjugated with a single-chain variable fragment antibody (scFv) towards mesothelin (MSLN), a biomarker for pancreatic most cancers (PC), …

Two Antibody-Guided Lactic-co-Glycolic Acid-Polyethylenimine (LGA-PEI) Nanoparticle Delivery Systems for Therapeutic Nucleic AcidsContinue reading