Engineered Osteoclasts Resorb Necrotic Alveolar Bone in Anti-RANKL Antibody-Treated Mice

Medicine-related osteonecrosis of the jaw (MRONJ) is a severe aspect impact of antiresorptive drugs resembling denosumab (humanized anti-RANKL antibody), but its pathophysiology stays elusive. It has been posited that inhibition of osteoclastic bone resorption results in the pathological sequelae of useless bone accumulation, impaired new bone formation, and poor wound therapeutic in MRONJ, however this …

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